App-V Error: 4A-40000194

There are a few possible problems here but I find the most common is that the OSD is not pointing to either the right location, deployment method, or both.

Check the OSD's (or go in via the Sequencer if you wish, but that will typically generate a new version of the .sft, though I haven't tried in 4.6SP1, maybe that was one of the two things they got right) to ensure the correct method and location are specified.

Remember that typically speaking it will be something like:
":<port>/<appsubfolder>/<pathtosft>"

And seldom if ever:
":<port>/<pathtosft>"